Filitra 40 mg contains Vardenafil, a phosphodiesterase type 5 (PDE5) inhibitor, used to treat erectile dysfunction (ED). Here’s how it works at a physiological level:

Inhibition of PDE5: Vardenafil inhibits the enzyme phosphodiesterase type 5 (PDE5). This enzyme breaks down cyclic guanosine monophosphate (cGMP), a molecule that is important for the regulation of blood flow in the penis.

Increased cGMP Levels: By inhibiting PDE5, Filitra 40 mg prevents the breakdown of cGMP. This leads to increased levels of cGMP in the smooth muscle cells of the penis.

Relaxation of Smooth Muscles: Elevated levels of cGMP cause relaxation of the smooth muscles in the blood vessels of the penis. This relaxation allows the blood vessels to dilate (widen).

Increased Blood Flow: The dilation of blood vessels enhances blood flow into the penis, leading to increased blood volume within the penile tissues.

Achieving and Maintaining an Erection: With increased blood flow, the penis becomes engorged and firm, leading to an erection. The erection is sustained as long as there is sexual stimulation, which is necessary for Vardenafil to exert its effects.

Return to Normal State: After ejaculation or the end of sexual stimulation, the effects of Vardenafil gradually wear off, and the PDE5 enzyme resumes its activity, breaking down cGMP and returning the penis to its flaccid state.

Timing and Duration: Filitra 40 mg typically takes about 30 to 60 minutes to start working and can remain effective for up to 4 to 6 hours. This duration allows for a window of opportunity for sexual activity.

Filitra 40 mg works specifically by targeting the physiological mechanisms involved in achieving and maintaining an erection, focusing on the regulation of blood flow in the penis through the inhibition of PDE5.